9 Hormones That Affect Your Weight — and How to Improve Them

Leptin is a fullness hormone that works by telling your hypothalamus — the portion of your brain that regulates appetite — that you’re full (18Trusted Source).

However, people with obesity may experience leptin resistance. This means the message to stop eating doesn’t reach your brain, eventually causing you to overeat (18Trusted Source).

In turn, your body may produce even more leptin until your levels become elevated (18Trusted Source).

The direct cause of leptin resistance is unclear, but it may be due to inflammation, gene mutations, and/or excessive leptin production, which can occur with obesity (19Trusted Source).

Tips to improve leptin levels

Although no known treatment exists for leptin resistance, a few lifestyle changes may help lower leptin levels (18Trusted Source):


In people with obesity, resistance to the hormone leptin, which helps you feel full, may lead to overeating. Research suggests that exercising regularly, sleeping well, and maintaining a healthy body weight help lower leptin levels.

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